Multiple courses of ancrod (Arvin) therapy.

Further experience in the use of ancrod (Arvin) to prevent thrombosis on prosthetic heart valves.

Intravenous administration of ancrod produces hypofibrinogenaemia, which may be prolonged by further doses. Hypofibrinogenaemia, maintained for a week, was used to prevent thrombosis on prosthetic heart valves in the calf. Thirteen calves were used in the study. Three of these were used to determine dose schedules and to test antibody formation. The calf was found to have hyperactive fibrinogen...

Courses of malignant pheochromocytoma: implications for therapy.

Survival of patients with metastatic pheochromocytoma that have exceeded 30 years without therapy to reduce tumors have been reported. We reviewed the records of 38 patients with malignant pheochromocytoma who had received 131I-metaiodiobenzylguanidine (131I-MIBG) treatments between 1981 and 1996 to evaluate longevity. Survival from diagnosis to last follow-up exceeded 5 years in 21 of 38 (55%)...

Lymphaticovenous anastomosis for facial lymphoedema after multiple courses of therapy for head-and-neck cancer.

Lymphaticovenous anastomosis (LVA) is a treatment for lymphoedema that can improve lymph circulation by the anastomosis of lymph vessels and veins. A therapeutic effect of LVA for lymphoedema has been shown in limbs, but efficacy for other regions has not been shown. Lymphoedema in the head-and-neck region following cancer resection and radiotherapy is mainly treated with manual lymphatic drain...

Experimental dysfibrinogenemia: in vivo studies with arvin.

Multiple dopamine functions at different time courses.

Many lesion studies report an amazing variety of deficits in behavioral functions that cannot possibly be encoded in great detail by the relatively small number of midbrain dopamine neurons. Although hoping to unravel a single dopamine function underlying these phenomena, electrophysiological and neurochemical studies still give a confusing, mutually exclusive, and partly contradictory account ...